Salvia Officinalis Oil Improves the Atherogenic Index and Cardiotoxicity in Albino Rats Treated with 5- Fluorouracil

5-Fluorouracil is reported as the second most common chemotherapeutic agent after anthracyclines causing cardiotoxicity. Thirty male albino rats were divided into three groups. Rats in group I received saline daily for 8 days only and served as the control. Rats in group II received saline orally for 8 days, then administrated with 5-Fluorouracil (150mg\ kg B.W\once I.P injection at the 5 day). Rats in group III were orally dosed with Salvia. officinalis oil (0.4ml\ kg B.W\day) for 8 days and at the 5 day, were administrated with the same previous dose of 5-Fluorouracil. 5-Fluorouracil induced a significant increase in serum concentrations of cTnI, CK-MB and MDA concentration in cardiac homogenate. 5-Fluorouracil significantly decreased GSH concentration in cardiac homogenate and altered serum lipid profile. Its administration also resulted in release of some inflammatory markers such as IL-1β and myeloperoxidase. Salvia officinalis oil pre-co-post-treatment ameliorated the altered parameters caused by 5Fluorouracil induced cardiotoxicity in rats.